Retina & Vitreous · NEET PG Preparation Ophthalmology
A 65-year-old female presents with progressive distortion of straight lines (metamorphopsia) and decreased central vision in her left eye over the pa…
Practice question from Retina & Vitreous (NEET PG Preparation Ophthalmology), with the correct answer and a step-by-step solution.
medium · MCQ · Q-AD3E98
A 65-year-old female presents with progressive distortion of straight lines (metamorphopsia) and decreased central vision in her left eye over the past few months. Optical coherence tomography (OCT) shows subretinal fluid and a fibrovascular membrane originating from the choroid. Which of the following is the primary mediator responsible for the choroidal neovascularization in this condition?
- A.Tumor necrosis factor-alpha
- B.Vascular endothelial growth factorCorrect answer
- C.Transforming growth factor-beta
- D.Fibroblast growth factor
Solution
The patient has wet (neovascular) age-related macular degeneration (ARMD). Vascular endothelial growth factor (VEGF) plays a critical role in promoting the growth of abnormal choroidal blood vessels (choroidal neovascularization, CNV) beneath the retina, which can bleed and lead to disciform scars. Anti-VEGF intravitreal injections are the mainstay of treatment.
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