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Principles of Inheritance and Variation cheat sheet

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NEET · Botany

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Class 12 · Chapter 3Principles of Inheritance and Variation

Mendel's ratios: monohybrid 3 : 1, dihybrid 9 : 3 : 3 : 1, test cross 1 : 1.

1. Mendel's Laws

  • Law of dominance.
  • Law of segregation (purity of gametes).
  • Law of independent assortment (dihybrid cross).

2. Deviations

PatternExampleF₂ ratio
Incomplete dominancesnapdragon flower colour1 : 2 : 1
Co-dominanceABO blood group (Iᴬ Iᴮ)1 : 2 : 1
Multiple allelesABO (3 alleles)—
Pleiotropyphenylketonuria—
Polygenichuman skin colourcontinuous

3. Chromosomal Theory

  • Sutton and Boveri.
  • Morgan (Drosophila): linkage and recombination.
  • Sex determination: XX–XY (humans), XX–XO (grasshopper), ZW–ZZ (birds).

4. Disorders

DisorderType
Haemophilia, colour blindnessX-linked recessive
Sickle-cell anaemiaautosomal recessive (Glu → Val)
Thalassaemiaautosomal recessive
Down's syndrometrisomy 21
Klinefelter'sXXY
Turner'sXO

5. Key Points

  • Test cross reveals genotype.
  • Linked genes are inherited together.
  • Pedigree analysis traces traits.
  • Mutations: point, frameshift.

Remember: 3 laws | deviations | sex determination | disorders

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