Cell Injury & Inflammation · NEET PG Preparation Pathology
A 54-year-old male presents with acute chest pain. An electrocardiogram confirms an acute anterior wall myocardial infarction. He undergoes emergent…
Practice question from Cell Injury & Inflammation (NEET PG Preparation Pathology), with the correct answer and a step-by-step solution.
medium · MCQ · Q-02477C
A 54-year-old male presents with acute chest pain. An electrocardiogram confirms an acute anterior wall myocardial infarction. He undergoes emergent percutaneous coronary intervention with stent placement. However, reperfusion of the ischemic myocardium often leads to paradoxical exacerbation of cell injury and further release of cardiac enzymes. Which of the following is the primary mediator responsible for this reperfusion injury?
- A.Reactive oxygen species (ROS)Correct answer
- B.Complement component C5a
- C.Intracellular accumulation of triglycerides
- D.Depletion of nuclear DNA polymerases
Solution
Reperfusion injury following ischemia is primarily mediated by the generation of reactive oxygen species (ROS) from damaged mitochondrial electron transport chains and infiltrating neutrophils, along with a massive influx of calcium.
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