Cell Injury & Inflammation · NEET PG Preparation Pathology
A 45-year-old chronic alcoholic undergoes a routine health check-up. An abdominal ultrasound reveals hepatomegaly with diffuse increased echogenicity…
Practice question from Cell Injury & Inflammation (NEET PG Preparation Pathology), with the correct answer and a step-by-step solution.
medium · MCQ · Q-863233
A 45-year-old chronic alcoholic undergoes a routine health check-up. An abdominal ultrasound reveals hepatomegaly with diffuse increased echogenicity, characteristic of hepatic steatosis. Which of the following biochemical alterations is the primary cause of triglyceride accumulation within the hepatocytes in this patient?
- A.Decreased synthesis of apolipoproteins
- B.Increased peripheral mobilization of free fatty acids
- C.Inhibition of mitochondrial beta-oxidation by excess NADHCorrect answer
- D.Increased uptake of dietary chylomicron remnants
Solution
Chronic alcohol metabolism generates excessive NADH, which shifts metabolic pathways to favor reduced products, thereby inhibiting mitochondrial beta-oxidation of fatty acids and leading to their accumulation as triglycerides.
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