Cell Injury & Inflammation · NEET PG Preparation Pathology
A 28-year-old female presents with recurrent oral and genital aphthous ulcers, along with painful erythematous nodules on her shins. Skin biopsy of a…
Practice question from Cell Injury & Inflammation (NEET PG Preparation Pathology), with the correct answer and a step-by-step solution.
hard · MCQ · Q-31181F
A 28-year-old female presents with recurrent oral and genital aphthous ulcers, along with painful erythematous nodules on her shins. Skin biopsy of a nodule shows a leukocytoclastic vasculitis with prominent neutrophil infiltration and nuclear debris (karyorrhexis). Which of the following adhesion molecules is primarily deficient or defective in leukocyte adhesion deficiency type 1 (LAD-1), which impairs similar acute inflammatory responses?
- A.P-selectin (CD62P)
- B.E-selectin (CD62E)
- C.LFA-1 (CD11aCD18)Correct answer
- D.ICAM-1 (CD54)
Solution
Leukocyte Adhesion Deficiency type 1 (LAD-1) is caused by mutations in the ITGB2 gene encoding the beta-2 integrin subunit (CD18), which is part of LFA-1 (CD11aCD18). This impairs firm adhesion and transmigration of neutrophils.
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