Cell Injury & Inflammation · NEET PG Preparation Pathology
A 32-year-old male sustains a deep puncture wound to his foot while walking barefoot. Three days later, the wound is painful, swollen, and exudes thi…
Practice question from Cell Injury & Inflammation (NEET PG Preparation Pathology), with the correct answer and a step-by-step solution.
medium · MCQ · Q-BCDFBD
A 32-year-old male sustains a deep puncture wound to his foot while walking barefoot. Three days later, the wound is painful, swollen, and exudes thick, creamy yellow pus. Gram stain of the exudate shows numerous Gram-positive cocci and degenerate polymorphonuclear neutrophils. What is the predominant mechanism of killing utilized by these neutrophils against the bacteria?
- A.Complement-mediated membrane attack complex (MAC)
- B.Myeloperoxidase-mediated ROS-hypochlorite systemCorrect answer
- C.Perforin and granzyme release via cytotoxic T-cells
- D.Nitric oxide synthesis via inducible NOS in the absence of oxygen
Solution
Neutrophils utilize the oxygen-dependent respiratory burst. Superoxide is converted to hydrogen peroxide, which myeloperoxidase combines with halide ions (like Cl-) to form hypochlorite, a potent microbicidal agent.
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