CNS, Endocrine & Bone Pathology · NEET PG Preparation Pathology
A 30-year-old pregnant woman presents with palpitations, heat intolerance, weight loss, and fine tremors. Laboratory tests confirm hyperthyroidism. G…
Practice question from CNS, Endocrine & Bone Pathology (NEET PG Preparation Pathology), with the correct answer and a step-by-step solution.
easy · MCQ · Q-0780A6
A 30-year-old pregnant woman presents with palpitations, heat intolerance, weight loss, and fine tremors. Laboratory tests confirm hyperthyroidism. Gross examination of the resected thyroid gland shows diffuse, symmetric enlargement. Microscopic examination reveals tall, crowded follicular cells forming papillary infoldings into the colloid, with scalloping of the margins of the colloid. Which of the following autoantibodies is primarily responsible for this disorder?
- A.Anti-thyroperoxidase (Anti-TPO)
- B.Anti-thyroglobulin
- C.Thyroid-stimulating immunoglobulin (TSI)Correct answer
- D.Anti-TSH receptor blocking antibody
Solution
Graves disease is caused by thyroid-stimulating immunoglobulins (TSIs), which are IgG antibodies that bind to and activate the TSH receptor, leading to unregulated thyroid hormone synthesis and diffuse hyperplasia of the thyroid gland.
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