CNS, Endocrine & Bone Pathology · NEET PG Preparation Pathology
A 45-year-old man presents with progressive bitemporal hemianopsia and signs of panhypopituitarism. Magnetic resonance imaging reveals a large supras…
Practice question from CNS, Endocrine & Bone Pathology (NEET PG Preparation Pathology), with the correct answer and a step-by-step solution.
medium · MCQ · Q-9C7B76
A 45-year-old man presents with progressive bitemporal hemianopsia and signs of panhypopituitarism. Magnetic resonance imaging reveals a large suprasellar cystic mass containing thick, machine-oil-like fluid and areas of calcification. Histological examination shows nests and cords of stratified squamous epithelium with palisading basal cells and wet keratin. Which of the following is the most likely diagnosis?
- A.Pituitary adenoma
- B.Craniopharyngioma (adamantinomatous type)Correct answer
- C.Rathke cleft cyst
- D.Meningioma
Solution
Adamantinomatous craniopharyngioma is derived from Rathke pouch remnants and characteristically presents in children and young/middle-aged adults with a suprasellar mass, calcifications, cystic spaces filled with 'machine-oil' fluid, and histology showing wet keratin, calcification, and palisading squamous epithelium.
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