CNS, Endocrine & Bone Pathology · NEET PG Preparation Pathology
A 55-year-old woman presents with severe fatigue, weight gain, cold intolerance, and constipation. Laboratory tests show low free T4 and significantl…
Practice question from CNS, Endocrine & Bone Pathology (NEET PG Preparation Pathology), with the correct answer and a step-by-step solution.
easy · MCQ · Q-634F1C
A 55-year-old woman presents with severe fatigue, weight gain, cold intolerance, and constipation. Laboratory tests show low free T4 and significantly elevated TSH. Histological evaluation of her thyroid gland demonstrates a dense mononuclear infiltrate composed of lymphocytes and plasma cells with germinal center formation, along with oxyphilic metaplasia (Hürthle cells) of the follicular epithelium. What is the most likely diagnosis?
- A.Subacute granulomatous thyroiditis
- B.Hashimoto thyroiditisCorrect answer
- C.Riedel thyroiditis
- D.Graves disease
Solution
Hashimoto thyroiditis is an autoimmune condition characterized by a depleted thyroid parenchyma replaced by extensive lymphocytic infiltration with germinal centers, plasma cells, and characteristic Hürthle (Askanazy) cells. It is the most common cause of hypothyroidism in iodine-sufficient areas.
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