CNS, Endocrine & Bone Pathology · NEET PG Preparation Pathology
A 10-year-old boy presents with unsteady gait, frequent stumbling, and behavioral changes. Magnetic resonance imaging shows a large cystic cerebellar…
Practice question from CNS, Endocrine & Bone Pathology (NEET PG Preparation Pathology), with the correct answer and a step-by-step solution.
medium · MCQ · Q-C3F8B9
A 10-year-old boy presents with unsteady gait, frequent stumbling, and behavioral changes. Magnetic resonance imaging shows a large cystic cerebellar mass with a mural nodule. Histological examination reveals bipolar cells with long, thin hair-like processes (Rosenthal fibers) and eosinophilic granular bodies. Which of the following is the most likely diagnosis?
- A.Medulloblastoma
- B.Pilocytic astrocytomaCorrect answer
- C.Ependymoma
- D.Subependymoma
Solution
Pilocytic astrocytoma is a low-grade (WHO Grade 1) glioma typically seen in children and young adults, frequently arising in the cerebellum. Histology classically shows biphasic architecture with microcysts, bipolar astrocytes with hair-like processes, Rosenthal fibers, and eosinophilic granular bodies.
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