CNS, Endocrine & Bone Pathology · NEET PG Preparation Pathology
A 60-year-old chronic smoker presents with a progressively worsening headache and a single seizure episode. Brain imaging reveals a well-circumscribe…
Practice question from CNS, Endocrine & Bone Pathology (NEET PG Preparation Pathology), with the correct answer and a step-by-step solution.
hard · MCQ · Q-915D7B
A 60-year-old chronic smoker presents with a progressively worsening headache and a single seizure episode. Brain imaging reveals a well-circumscribed, ring-enhancing cortical mass in the frontal lobe with extensive surrounding vasogenic edema. Stereotactic biopsy shows highly cellular glial tumor tissue with pseudopalisading necrosis and microvascular proliferation. Immunohistochemistry is positive for IDH1-R132H mutation. Which of the following is the final World Health Organization (WHO) CNS grade for this tumor?
- A.WHO Grade 1
- B.WHO Grade 2
- C.WHO Grade 3
- D.WHO Grade 4Correct answer
Solution
Glioblastoma, IDH-mutant or IDH-wildtype, is defined by the presence of microvascular proliferation and/or pseudopalisading necrosis, making it a WHO Grade 4 astrocytic tumor, which is the most malignant and common primary brain tumor in adults.
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