Anticancer & Immunosuppressants · NEET PG Preparation Pharmacology
A 54-year-old man with metastatic colorectal cancer is scheduled to receive a chemotherapy regimen containing 5-fluorouracil (5-FU). To enhance the c…
Practice question from Anticancer & Immunosuppressants (NEET PG Preparation Pharmacology), with the correct answer and a step-by-step solution.
medium · MCQ · Q-23E3B9
A 54-year-old man with metastatic colorectal cancer is scheduled to receive a chemotherapy regimen containing 5-fluorouracil (5-FU). To enhance the cytotoxic efficacy of 5-FU by increasing the stability of its inhibitory ternary complex with thymidylate synthase, which of the following agents is co-administered?
- A.Leucovorin (Folinic acid)Correct answer
- B.Mesna
- C.Dexrazoxane
- D.Allopurinol
Solution
Leucovorin is administered with 5-FU to provide reduced folate pools, which stabilizes the ternary complex formed by FdUMP (the active metabolite of 5-FU), thymidylate synthase, and reduced folate, thereby increasing the drug's cytotoxicity. Mesna is used to prevent hemorrhagic cystitis caused by oxazaphosphorines. Dexrazoxane is an iron chelator used to prevent anthracycline-induced cardiotoxicity.
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