Anticancer & Immunosuppressants · NEET PG Preparation Pharmacology
Which of the following immunosuppressive agents acts primarily by inhibiting calcineurin, thereby preventing the dephosphorylation and nuclear transl…
Practice question from Anticancer & Immunosuppressants (NEET PG Preparation Pharmacology), with the correct answer and a step-by-step solution.
easy · MCQ · Q-A7A757
Which of the following immunosuppressive agents acts primarily by inhibiting calcineurin, thereby preventing the dephosphorylation and nuclear translocation of the nuclear factor of activated T cells (NFAT)?
- A.Sirolimus
- B.TacrolimusCorrect answer
- C.Mycophenolate mofetil
- D.Basiliximab
Solution
Tacrolimus and cyclosporine are calcineurin inhibitors. They bind to immunophilins (FKBP and cyclophilin, respectively) and inhibit calcineurin phosphatase activity, blocking NFAT activation and subsequent IL-2 transcription. Sirolimus inhibits mTOR. Mycophenolate inhibits inosine monophosphate dehydrogenase. Basiliximab is an anti-IL-2 receptor monoclonal antibody.
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