Anticancer & Immunosuppressants · NEET PG Preparation Pharmacology
A 45-year-old woman undergoing chemotherapy with cisplatin experiences severe, intractable nausea and vomiting. Which of the following receptor antag…
Practice question from Anticancer & Immunosuppressants (NEET PG Preparation Pharmacology), with the correct answer and a step-by-step solution.
easy · MCQ · Q-EE7687
A 45-year-old woman undergoing chemotherapy with cisplatin experiences severe, intractable nausea and vomiting. Which of the following receptor antagonism is the primary mechanism of action for drugs like ondansetron used to manage this condition?
- A.Dopamine D2 receptors in the chemoreceptor trigger zone
- B.Serotonin 5-HT3 receptors on vagal afferents and in the CNSCorrect answer
- C.Neurokinin-1 (NK1) receptors in the nucleus tractus solitarius
- D.Histamine H1 receptors in the vestibular system
Solution
Ondansetron and other 5-HT3 receptor antagonists block serotonin receptors located peripherally on vagal nerve terminals in the gastrointestinal tract and centrally in the chemoreceptor trigger zone (CTZ) and nucleus tractus solitarius, making them highly effective against chemotherapy-induced emesis.
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