Anticancer & Immunosuppressants · NEET PG Preparation Pharmacology
A renal transplant recipient is prescribed an immunosuppressant that acts as a prodrug converted to mycophenolic acid. Which of the following is the…
Practice question from Anticancer & Immunosuppressants (NEET PG Preparation Pharmacology), with the correct answer and a step-by-step solution.
medium · MCQ · Q-6D6E8C
A renal transplant recipient is prescribed an immunosuppressant that acts as a prodrug converted to mycophenolic acid. Which of the following is the specific intracellular enzyme inhibited by mycophenolic acid?
- A.Dihydrofolate reductase
- B.Inosine monophosphate dehydrogenaseCorrect answer
- C.HMG-CoA reductase
- D.Calcineurin phosphatase
Solution
Mycophenolate mofetil is hydrolyzed to mycophenolic acid, which is a potent, reversible, uncompetitive inhibitor of inosine monophosphate dehydrogenase (IMPDH). IMPDH is the rate-limiting enzyme in de novo guanosine nucleotide synthesis, which lymphocytes depend on heavily for proliferation.
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