Lipid Metabolism · NEET PG Preparation Biochemistry
A researcher is studying fatty acid oxidation in isolated rat liver mitochondria. She adds palmitoyl-CoA to the preparation but notes that no beta-ox…
Practice question from Lipid Metabolism (NEET PG Preparation Biochemistry), with the correct answer and a step-by-step solution.
medium · MCQ · Q-2E49E5
A researcher is studying fatty acid oxidation in isolated rat liver mitochondria. She adds palmitoyl-CoA to the preparation but notes that no beta-oxidation occurs unless she also adds carnitine. Which of the following enzymes is directly responsible for transferring the acyl group from CoA to carnitine?
- A.Carnitine palmitoyltransferase I (CPT-I)Correct answer
- B.Carnitine acylcarnitine translocase
- C.Carnitine palmitoyltransferase II (CPT-II)
- D.Acyl-CoA synthetase
Solution
Carnitine palmitoyltransferase I (CPT-I), located on the outer mitochondrial membrane, catalyzes the transfer of the acyl group from fatty acyl-CoA to carnitine to form acylcarnitine, which is the rate-limiting step of fatty acid entry into mitochondria.
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