Lipid Metabolism · NEET PG Preparation Biochemistry
During fasting, the liver produces ketone bodies (acetoacetate, beta-hydroxybutyrate, and acetone) to supply energy to extrahepatic tissues like the…
Practice question from Lipid Metabolism (NEET PG Preparation Biochemistry), with the correct answer and a step-by-step solution.
hard · MCQ · Q-5DEDA0
During fasting, the liver produces ketone bodies (acetoacetate, beta-hydroxybutyrate, and acetone) to supply energy to extrahepatic tissues like the brain and skeletal muscle. Which of the following is the rate-limiting enzyme in hepatic ketogenesis?
- A.HMG-CoA reductase
- B.HMG-CoA synthase (mitochondrial)Correct answer
- C.Thiolase
- D.HMG-CoA lyase
Solution
Mitochondrial HMG-CoA synthase is the rate-limiting enzyme of ketogenesis in the liver. Note that cytosolic HMG-CoA synthase is involved in cholesterol synthesis.
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