Endocrine Drugs & Autacoids · NEET PG Preparation Pharmacology
A 28-year-old pregnant woman in her first trimester is diagnosed with hyperthyroidism due to Graves' disease. Which of the following antithyroid medi…
Practice question from Endocrine Drugs & Autacoids (NEET PG Preparation Pharmacology), with the correct answer and a step-by-step solution.
medium · MCQ · Q-783B0F
A 28-year-old pregnant woman in her first trimester is diagnosed with hyperthyroidism due to Graves' disease. Which of the following antithyroid medications is preferred during this specific gestational period to minimize teratogenic risks associated with other agents?
- A.Methimazole
- B.PropylthiouracilCorrect answer
- C.Radioactive iodine (I-131)
- D.Potassium iodide
Solution
Propylthiouracil (PTU) is preferred during the first trimester of pregnancy because methimazole has been associated with aplasia cutis and choanal atresia. PTU is switched to methimazole in the second trimester due to the risk of PTU-induced severe hepatotoxicity.
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