Endocrine Drugs & Autacoids · NEET PG Preparation Pharmacology
Which of the following oral antidiabetic drugs carries a black box warning for causing or worsening congestive heart failure and is contraindicated i…
Practice question from Endocrine Drugs & Autacoids (NEET PG Preparation Pharmacology), with the correct answer and a step-by-step solution.
medium · MCQ · Q-E61E64
Which of the following oral antidiabetic drugs carries a black box warning for causing or worsening congestive heart failure and is contraindicated in NYHA Class III and IV heart failure?
- A.Metformin
- B.Glimepiride
- C.PioglitazoneCorrect answer
- D.Acarbose
Solution
Thiazolidinediones like pioglitazone cause fluid retention and plasma volume expansion, which can precipitate or exacerbate heart failure, making them contraindicated in NYHA Class III and IV heart failure.
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