Endocrine Drugs & Autacoids · NEET PG Preparation Pharmacology
A 55-year-old male with severe chronic asthma requires long-term systemic corticosteroid therapy. Which of the following adverse metabolic effects is…
Practice question from Endocrine Drugs & Autacoids (NEET PG Preparation Pharmacology), with the correct answer and a step-by-step solution.
medium · MCQ · Q-F136CC
A 55-year-old male with severe chronic asthma requires long-term systemic corticosteroid therapy. Which of the following adverse metabolic effects is most characteristically associated with chronic glucocorticoid excess?
- A.Hypoglycemia and increased peripheral insulin sensitivity
- B.Central fat redistribution, muscle wasting, and hyperglycemiaCorrect answer
- C.Hyperkalemia and metabolic acidosis
- D.Weight loss and hyperpigmentation
Solution
Glucocorticoids promote gluconeogenesis, inhibit peripheral glucose uptake, and cause insulin resistance leading to hyperglycemia. They also cause protein catabolism (muscle wasting) and central redistribution of fat (Cushingoid features).
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