Endocrine Drugs & Autacoids · NEET PG Preparation Pharmacology
A 34-year-old female presents with symptoms of weight gain, fatigue, cold intolerance, and constipation. Laboratory investigations reveal primary hyp…
Practice question from Endocrine Drugs & Autacoids (NEET PG Preparation Pharmacology), with the correct answer and a step-by-step solution.
easy · MCQ · Q-F244DE
A 34-year-old female presents with symptoms of weight gain, fatigue, cold intolerance, and constipation. Laboratory investigations reveal primary hypothyroidism. She is prescribed levothyroxine. Which of the following is the primary mechanism of action of this drug?
- A.Inhibition of thyroid peroxidase
- B.Stimulation of nuclear receptors to alter gene transcription and protein synthesisCorrect answer
- C.Blockade of peripheral conversion of T4 to T3
- D.Direct activation of G-protein coupled thyrotropin receptors
Solution
Levothyroxine is synthetic T4. Thyroid hormones enter cells and bind to nuclear receptors (TR-alpha and TR-beta), which then modulate gene transcription and protein synthesis, regulating basal metabolic rate, thermogenesis, and growth.
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