Blood & Immunity · NEET PG Preparation Physiology
A 32-year-old pregnant woman with blood group O negative is found to have an indirect Coombs test positive at 28 weeks of gestation. Which of the fol…
Practice question from Blood & Immunity (NEET PG Preparation Physiology), with the correct answer and a step-by-step solution.
medium · MCQ · Q-8178E8
A 32-year-old pregnant woman with blood group O negative is found to have an indirect Coombs test positive at 28 weeks of gestation. Which of the following antibodies is primarily responsible for causing hemolytic disease of the newborn (HDN) in this clinical scenario?
- A.Naturally occurring IgM anti-A
- B.Naturally occurring IgM anti-B
- C.Immune IgG anti-DCorrect answer
- D.Immune IgA anti-AB
Solution
Hemolytic disease of the newborn (HDN) due to Rh incompatibility is caused by maternal IgG antibodies (such as anti-D) that cross the placenta and lyse fetal red blood cells. Naturally occurring antibodies (anti-A and anti-B) are predominantly IgM and do not cross the placenta.
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