Blood & Immunity · NEET PG Preparation Physiology
Which of the following interleukins is the primary endogenous pyrogen responsible for inducing the acute phase response and fever in the hypothalamus…
Practice question from Blood & Immunity (NEET PG Preparation Physiology), with the correct answer and a step-by-step solution.
easy · MCQ · Q-FC0E18
Which of the following interleukins is the primary endogenous pyrogen responsible for inducing the acute phase response and fever in the hypothalamus during an immune reaction?
- A.Interleukin-2
- B.Interleukin-4
- C.Interleukin-1Correct answer
- D.Interleukin-10
Solution
Interleukin-1 (IL-1), along with Tumor Necrosis Factor-alpha (TNF-alpha) and IL-6, acts as a potent endogenous pyrogen. They travel to the hypothalamus, stimulating the synthesis of prostaglandins (specifically PGE2), which elevate the hypothalamic thermal set point, causing fever.
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