Blood & Immunity · NEET PG Preparation Physiology
A patient with severe liver cirrhosis presents with a prolonged prothrombin time (PT) and international normalized ratio (INR), while the bleeding ti…
Practice question from Blood & Immunity (NEET PG Preparation Physiology), with the correct answer and a step-by-step solution.
medium · MCQ · Q-D0FB48
A patient with severe liver cirrhosis presents with a prolonged prothrombin time (PT) and international normalized ratio (INR), while the bleeding time is within normal limits. Deficiency of which of the following clotting factors is primarily responsible for the prolonged PT in liver disease?
- A.Factor VIII
- B.Factor IX
- C.Factor VIICorrect answer
- D.Factor von Willebrand
Solution
The liver synthesizes almost all coagulation factors. Factor VII has the shortest half-life (around 4-6 hours) among the vitamin K-dependent factors (II, VII, IX, X, Protein C, Protein S), making it the first to decrease significantly in acute or chronic liver failure, leading to an early prolongation of the PT.
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