Autonomic Nervous System Drugs · NEET PG Preparation Pharmacology
A patient with Parkinson disease is initiated on a selective MAO-B inhibitor. Which of the following drugs belongs to this class and is known to be m…
Practice question from Autonomic Nervous System Drugs (NEET PG Preparation Pharmacology), with the correct answer and a step-by-step solution.
medium · MCQ · Q-B6B4C1
A patient with Parkinson disease is initiated on a selective MAO-B inhibitor. Which of the following drugs belongs to this class and is known to be metabolized to amphetamine and methamphetamine derivatives?
- A.Rasagiline
- B.SelegilineCorrect answer
- C.Entacapone
- D.Safinamide
Solution
Selegiline (l-deprenyl) is a selective MAO-B inhibitor used in Parkinson disease. Its metabolism yields L-amphetamine and L-methamphetamine, which can cause central nervous system stimulation, insomnia, and positive amphetamine screens. Rasagiline and safinamide do not metabolize to amphetamine derivatives.
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