Autonomic Nervous System Drugs · NEET PG Preparation Pharmacology
A 45-year-old man undergoes surgery and receives a competitive neuromuscular blocker. At the end of the procedure, the anesthesiologist wishes to rev…
Practice question from Autonomic Nervous System Drugs (NEET PG Preparation Pharmacology), with the correct answer and a step-by-step solution.
easy · MCQ · Q-F84F3C
A 45-year-old man undergoes surgery and receives a competitive neuromuscular blocker. At the end of the procedure, the anesthesiologist wishes to reverse the blockade and administers neostigmine along with atropine. What is the primary reason for co-administering atropine?
- A.To prevent neostigmine-induced skeletal muscle fasciculations
- B.To prevent excessive muscarinic stimulation such as bradycardia and hypersalivationCorrect answer
- C.To enhance the neuromuscular blocking reversal effect at the motor endplate
- D.To prevent central nervous system depression caused by neostigmine
Solution
Neostigmine inhibits acetylcholinesterase, increasing acetylcholine at both neuromuscular junctions and muscarinic receptors (parasympathetic effect). This leads to undesirable muscarinic side effects such as severe bradycardia, bronchospasm, and hypersalivation. Atropine, a competitive muscarinic antagonist, is co-administered to block these peripheral muscarinic effects without affecting the nicotinic reversal at the skeletal neuromuscular junction.
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