Blood & Immunity

Topics in this chapter

• Blood Composition and Functions
• Erythropoiesis, Hemoglobin, and Anemia
• Blood Groups and Rh Factor
• Hemostasis and Coagulation
• Innate Immunity and Complement
• Adaptive and Mucosal Immunity
• Blood–Organ and Physiological Integration

Practice questions

1. Question 1Q-8178E8

   A 32-year-old pregnant woman with blood group O negative is found to have an indirect Coombs test positive at 28 weeks of gestation. Which of the following antibodies is primarily responsible for causing hemolytic disease of the newborn (HDN) in this clinical scenario?

   1. A.Naturally occurring IgM anti-A
   2. B.Naturally occurring IgM anti-B
   3. C.Immune IgG anti-D
   4. D.Immune IgA anti-AB
   See the answer and solution
2. Question 2Q-0FAF9A

   During the process of hemostasis, von Willebrand factor (vWF) plays a critical role in primary hemostasis. What is the primary function of vWF?

   1. A.Activation of factor XIII to stabilize fibrin polymers
   2. B.Mediating platelet adhesion to exposed subendothelial collagen
   3. C.Conversion of fibrinogen to fibrin monomers
   4. D.Inhibition of plasminogen activation
   See the answer and solution
3. Question 3Q-D0FB48

   A patient with severe liver cirrhosis presents with a prolonged prothrombin time (PT) and international normalized ratio (INR), while the bleeding time is within normal limits. Deficiency of which of the following clotting factors is primarily responsible for the prolonged PT in liver disease?

   1. A.Factor VIII
   2. B.Factor IX
   3. C.Factor VII
   4. D.Factor von Willebrand
   See the answer and solution
4. Question 4Q-FC0E18

   Which of the following interleukins is the primary endogenous pyrogen responsible for inducing the acute phase response and fever in the hypothalamus during an immune reaction?

   1. A.Interleukin-2
   2. B.Interleukin-4
   3. C.Interleukin-1
   4. D.Interleukin-10
   See the answer and solution
5. Question 5Q-9B8C81

   A 45-year-old male is diagnosed with pernicious anemia due to autoimmune destruction of gastric parietal cells. Which of the following laboratory findings is most characteristic of this condition?

   1. A.Microcytic hypochromic anemia with decreased serum ferritin
   2. B.Macrocytic anemia with hypersegmented neutrophils
   3. C.Normocytic normochromic anemia with positive direct Coombs test
   4. D.Normocytic anemia with target cells and basophilic stippling
   See the answer and solution